Exposure
- World War I Wartime Exposure
- Thermal or Ultraviolet Breakdown Product of Chlorinated Solvents: such as methylene chloride
- Common exposure from welding metals “degreased” with solvents
Physiology
- Phosgene Gas Inhalation
- Phosgene gas is not acutely irritating
- Low Water Solubility: may result in longer exposure and delayed injury to bronchioles and alveoli
Diagnosis
- FOB: may be necessary to rule out airway injury
Clinical
(delayed onset of symptoms -> appear 12-24 hrs after exposure)
- Bronchiolitis Obliterans (see Bronchiolitis Obliterans, [[Bronchiolitis Obliterans]])
- Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
- Pathology: diffuse alveolar damage
- Reactive Airway Dysfunction Syndrome (see Reactive Airway Dysfunction Syndrome, [[Reactive Airway Dysfunction Syndrome]])
Treatment
- Steroids: may be benficial in acute lung injury, but unproven
References
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