Pharmacology

• Contains Bergamottin
  • Moderate Cytochrome P450 3A4 (CYP3A4) Inhibitor
    • Impacts Metabolism of Medications Which Require CYP3A4 for Metabolism

---

Adverse Effects

Cardiovascular Adverse Effects

• QT Prolongation (see Torsade, [[Torsade]]): flavonoids in juice inhibit CYP3A4 (slowing metabolism of other medications) and directly inhibit the IKr channel -> QT prolongation

Pharmacologic Adverse Effects

Altered Metabolism of Certain Medications

• xxxx

Other Adverse Effects

• xxx

---

References

• xxx