Exposure

• Herbicide: aka Roundup (Roundup is glyphosate + surfactant)
  • Most commonly used herbicide in the US

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Physiology

• Glyphosate Ingestion
  • Toxicity may be related to the volume of the surfactant component (rather than the type of surfactant)
  • Caustic GI effects

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Clinical

GI Manifestations

• Abdominal Pain (see Abdominal Pain, [[Abdominal Pain]])
• GI Bleed (see GI Bleed, [[GI Bleed]])

Pulmonary Manifestations

• Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])

Cardiovascular Manifestations

• Hypotension/Shock (see Hypotension, [[Hypotension]])

Neuro Manifestations

• Delirium/Coma (see Coma, [[Coma]])
• Aseptic Meningitis (see Meningitis, [[Meningitis]])

Renal Manifestations

• Acute Kidney Injury (see Acute Kidney Injury, [[Acute Kidney Injury]])

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References

• Acute Poisoning with a Glyphosate-Surfactant Herbicide (‘Roundup’): A Review of 93 Cases. Hum Exp Toxicol January 1991 vol. 10 no. 1 1-8
• Surfactant volume is an essential element in human toxicity in acute glyphosate herbicide intoxication. December 2011, Vol. 49, No. 10 , Pages 892-899
• Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning. Clin Toxicol (Phila). 2011 Feb;49(2):118-20