Progressive Massive Fibrosis (PMF)


  • Berylliosis (see Beryllium, [[Beryllium]])
  • Coal Worker’s Pneumoconiosis (see Coal Worker’s Pneumoconiosis, [[Coal Workers Pneumoconiosis]]): conglomerate masses usually occur in the upper lung zones
  • Kaolin Pneumoconiosis (see Kaolin Pneumoconiosis, [[Kaolin Pneumoconiosis]])
  • Pneumoconiosis from Carbon Compounds: associated with carbon black, graphite, and oil shale
  • Silicosis (see Silicosis, [[Silicosis]]): conglomerate masses usually occur in the upper lung zones
  • Sarcoidosis (see Sarcoidosis, [[Sarcoidosis]]): conglomerate masses are usually near the hilae and are associated with surrounding paracitricial emphysema
  • Talc Pneumoconiosis (see Talc Pneumoconiosis, [[Talc Pneumoconiosis]])


  • Pulmonary Deposition of Dust with Subsequent Immunologic Reaction

Clinical Manifestations

Pulmonary Manifestations

  • Conglomerate Lung Masses: defined as exceeeding 1 cm (by CXR) or exceeding 2 cm (by pathologic exam)
    • Usually in upper lung zones (more common on right side)
    • Usually bilateral
    • Usually grow slowly in size and do not cavitate: if these features are present, consideration of malignancy should be considered
    • More common in taller patients
  • Restrictive Pulmonary Function Tests (PFT’s): usually present


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  • Exposure to respirable coalmine dust and incidence of progressive massive fibrosis. British journal of industrial medicine 1987; 44 (10): 661–72. PMC 1007898. PMID 3676119
  • Pneumoconiosis: Comparison of Imaging and Pathologic Findings. RadioGraphics, 2006;26:59-77
  • Occupational Interstitial Lung Disease. Clinics Chest Med, 2004;25:467-478
  • Imaging of Interstitial Lung Disease. Clinics Chest Med, 2004;25:455-465
  • Diseases Associated with Exposure to Silica and Nonfibrous Silicate Minerals. Arch Pathol Lab Med, 1988;112:673-720