Epidemiology

• Extremely rare (few isolated cases)
• Most cases reported in older patients (F>M)

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Physiology

• Hodgkin’s arising from lymphoid follicles or peribronchial lymph nodes

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Pathology

• Pathognomonic Reed-Sternberg cell

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Diagnosis

• OLB: usually required for diagnosis in reported cases

FOB: TBB may be diagnostic

CXR/Chest CT Pattern (usually unilateral, rarely bilateral, with upper lobe predominance):
1) Solitary Lung Nodules: with absence of hilar/mediastinal nodes (necessary to diagnose primary disease in lung)
2) Diffuse Infiltrates: as in #1
3) Cavitation: as in #1

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Clinical

• Symptoms/Signs:
  -B symptoms (common): fever/night sweats/ weight loss

See also Lung nodules/<3 Symptoms: -B symptoms (common): fever/ night sweats/ weight loss Signs:

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Treatment

• Disease Isolated to Lungs: surgery + XRT
• Disease with Lungs + Other Nodes: stage-dependent
• Extranodal Disease: chemo (controversial

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References

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