Phrenic Neuropathy




  • Acute Intermittent Porphyria (see Acute Intermittent Porphyria)
  • Chronic Inflammatory Demyelinating Polyneuropathy (see Chronic Inflammatory Demyelinating Polyneuropathy)
  • Critical Illness Polyneuropathy (see Critical Illness Polyneuropathy and ICU-Acquired Weakness)
  • Diabetic Neuropathy (see Diabetic Neuropathy)
  • Guillian-Barre Syndrome (see Guillian-Barre Syndrome): acute or subacute
    • Ascending paralysis (similar to tick paralysis and in contrast to descending paralysis seen in botulism and paralytic-neurotoxic shellfish poisoning)
  • Hypothyroidism (see Hypothyroidism)
    • Hypothyroidism-associated chronic hypoventilation is due to a combination of neuropathy, myopathy, and decreased drive
  • Idiopathic Peripheral Neuropathy
  • Mediastinal/Esophageal Surgical Injury or Traumatic Injury of Bilateral Phrenic Nerves
    • Phrenic nerve injury occurs in 2-20% of open heart surgery cases
    • L>R sided injury
    • Mechanisms: cold cardioplegia, dissection of LIMA, and/or stretching of phrenic nerve
  • Multiple Sclerosis (see Multiple Sclerosis)
  • Neurofibromatosis (see Neurofibromatosis): case report of bilateral diaphragmatic paralysis
  • Systemic Lupus Erythematosus (SLE) (see Systemic Lupus Erythematosus): neuropathy with vasculitis of phrenic nerves + myopathy



Clinical Features