Epidemiology

• Occurs only in patients with a history of childhood laryngeal papillomatosis (a viral disease of upper airway)

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Physiology

• Spread from upper airway to tracheobronchial tree in later years
• Benign lung neoplasm

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Diagnosis

• FOB: sessile or stalked multiple papillary growths (lined with flattened squamous epithelium)
  • EBB: diagnostic
• CXR: ateclectasis/post-obstructive pneumonia/ multiple nodular lesions (often cavitated)

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Clinical Presentations

• Hemoptysis:
• Asthmatic wheezing:
• Symptoms of Obstruction (see [[Obstructive Lung Disease]]
• Lung Nodules (see [[Lung Nodule or Mass]])
• Malignant transformation of nodule

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Treatment

• Surgery: resection is indicated where possible
• Interferon therapy: has been used, but neither curative or of long-term benefit

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References

• xxx