Multiple Laryngeal Papillomatosis
Epidemiology
- Occurs only in patients with a history of childhood laryngeal papillomatosis (a viral disease of upper airway)
Physiology
- Spread from upper airway to tracheobronchial tree in later years
- Benign lung neoplasm
Diagnosis
- FOB: sessile or stalked multiple papillary growths (lined with flattened squamous epithelium)
- CXR: ateclectasis/post-obstructive pneumonia/ multiple nodular lesions (often cavitated)
Clinical Presentations
- Hemoptysis:
- Asthmatic wheezing:
- Symptoms of Obstruction (see [[Obstructive Lung Disease]]
- Lung Nodules (see [[Lung Nodule or Mass]])
- Malignant transformation of nodule
Treatment
- Surgery: resection is indicated where possible
- Interferon therapy: has been used, but neither curative or of long-term benefit
References