Granular Cell Myoblastoma
Epidemiology
- Sex: M>F
- Age: usually presents between 30-50 y/o
Physiology
- Benign endobronchial tumor probably of neural origin (probably from Schwann cells)
- Can occur in many organs
Pathology
- Polygonal or spindle cells with granular cytoplasm
Clinical Presentations
- Lung Nodule (see Lung Nodule or Mass, [[Lung Nodule or Mass]])
- Epidemiology: rare presentation
- Diagnosis
- CXR/Chest CT: solitary nodule
- Endobronchial Lesion (see Obstructive Lung Disease, [[Obstructive Lung Disease]])
- Epidemiology: 50 reported cases
- Diagnosis
- FOB: usually occur in larynx or main bronchi (multiple in 10% of cases)
- Clinical
- Wheezing
- Cough
- Hemoptysis
- Recurrent infections
- Atelectasis/Post-Obstructive Pneumonia
Treatment
- Bronchoscopic Removal: occasionally possible
- Surgery: resection is advisable (especially for lesions >8 mm), due to propensity for local invasiveness and tendency to recur after limited excision
References