Diffuse Pulmonary Ossification (DPO)


Epidemiology

History

  • Luschka first described DPO in 1856

Etiology

Cardiac Disease

  • Chronic Congestive Heart Failure (CHF) (see Congestive Heart Failure)
    • Epidemiology: has been associated with the nodular form of disease
    • Physiology: passive congestion results in extravasation of red blood cells with deposition of hemosiderin into alveolar walls -> inflammation, fibrosis, and hyalinization
  • Hypertrophic Subaortic Stenosis (see xxxx)
    • Epidemiology: has been associated with the nodular form of disease
  • Mitral Stenosis (see Mitral Stenosis)
    • Epidemiology: has been associated with the nodular form of disease

Other

  • Acute Respiratory Distress Syndrome (ARDS) (see Acute Respiratory Distress Syndrome)
    • Epidemiology: has been associated with the dendriform type of disease
  • Asbestosis (see Asbestos)
    • Epidemiology: has been associated with the dendriform type of disease
  • Chronic Obstructive Pulmonary Disease (COPD) (see Chronic Obstructive Pulmonary Disease
    • Epidemiology: has been associated with the dendriform type of disease
  • Diabetes Mellitus (see Diabetes Mellitus)
    • Epidemiology: unclear if diabetes mellitus is a risk factor
  • Diffuse Alveolar Hemorrhage (DAH) (see Diffuse Alveolar Hemorrhage)
  • Heavy Metal Exposure (see xxxx)
    • Epidemiology: has been associated with the dendriform type of disease
  • Idiopathic Pulmonary Fibrosis (IPF) (see Idiopathic Pulmonary Fibrosis)
    • Epidemiology: has been associated with the dendriform type of disease
  • Organizing Pneumonia (see Cryptogenic Organizing Pneumonia
    • Epidemiology: has been associated with the dendriform type of disease
  • Rare Earth Pneumoconiosis (see xxxx, [[xxxx]])
    • Epidemiology: has been associated with the dendriform type of disease
  • Recurrent Aspiration Pneumonia (see Aspiration Pneumonia)
  • Solid Organ Transplant

Physiology


Diagnosis

Serum Chemistry

Serum Alkaline Phosphatase (see Serum Alkaline Phosphatase)

High-Resolution Chest CT (HRCT) (see High-Resolution Chest Computed Tomography)

Bone Scan (see Bone Scan)

Bronchoscopy (see Bronchoscopy)

Pulmonary Function Tests (PFT’s) (see Pulmonary Function Tests)

Video-Assisted Thoracoscopy (VATS) with Lung Biopsy (see Video-Assisted Thoracoscopic Surgery)


Clinical Manifestations

General Comments

Pulmonary Manifestations

Pulmonary Calcifications


Treatment

Therapies without Clinical Efficacy


References