Reported mostly in smokers (mostly in middle-aged and older males)
Etiology
xxx
Physiology
Malignant lung neoplasm
Invades locally and metastasizes to lung/ lymph nodes/ bones/ brain/ adrenal glands
Pathology
Malignant mature epithelium, non-small cell carcinoma surroun-ded by malignant mesenchymal elements (either primitive spindle cells or more differentiated sarcoma-type cells)
Diagnosis
FOB: useful in same manner as for NSC lung cancer
CXR/Chest CT patterns:
Airway lesion:
Parenchymal mass:
Clinical
Symptoms/Signs (staging is same as for NSC lung cancer):
Obstructive symptoms/ signs (with airway lesions): cough/ etc.
Symptoms/ signs related to lung mass (with parenchymal mass):
Treatment
Treatment is same as for NSC lung cancer
Surgery: preferred
XRT: useful for non-surgical candidates
Chemo: useful for palliation only
Prognosis
Better prognosis for tumors with less-differentiated sarcomatous matrix (resembling fibrosarcoma)