Carcinosarcoma

Epidemiology

  • Reported mostly in smokers (mostly in middle-aged and older males)

Etiology

  • xxx

Physiology

  • Malignant lung neoplasm
  • Invades locally and metastasizes to lung/ lymph nodes/ bones/ brain/ adrenal glands

Pathology

  • Malignant mature epithelium, non-small cell carcinoma surroun-ded by malignant mesenchymal elements (either primitive spindle cells or more differentiated sarcoma-type cells)

Diagnosis

  • FOB: useful in same manner as for NSC lung cancer
  • CXR/Chest CT patterns:
    • Airway lesion:
    • Parenchymal mass:

Clinical

  • Symptoms/Signs (staging is same as for NSC lung cancer):
  • Obstructive symptoms/ signs (with airway lesions): cough/ etc.
  • Symptoms/ signs related to lung mass (with parenchymal mass):

Treatment

  • Treatment is same as for NSC lung cancer
  • Surgery: preferred
  • XRT: useful for non-surgical candidates
  • Chemo: useful for palliation only

Prognosis

  • Better prognosis for tumors with less-differentiated sarcomatous matrix (resembling fibrosarcoma)

References

  • xx