Serum Immunoglobulin E (IgE)
Etiology of Elevated Serum Immunoglobulin E
Atopic Disease
Immunodeficiency
Atypical Complete DiGeorge Syndrome
Hyper IgE-Recurrent Infection Syndrome (Job’s Syndrome, Buckley-Job Syndrome) (see Hyper IgE-Recurrent Infection Syndrome , [[Hyper IgE-Recurrent Infection Syndrome]])
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX)
Netherton Disease
Omenn Syndrome
Wiskott-Aldrich Syndrome
Infectious Disease
Viral
Bacterial
Fungal
Parasitic
Ascariasis (see Ascariasis , [[Ascariasis]])
Schistosomiasis (see Schistosomiasis , [[Schistosomiasis]])
Strongyloidiasis (see Strongyloidiasis , [[Strongyloidiasis]])
Tropical Pulmonary Eosinophilia (see Tropical Pulmonary Eosinophilia , [[Tropical Pulmonary Eosinophilia]]): serum IgE usually >10,000 ng/mL (4200 IU/mL)
Wuchereria Bancrofti
Brugia Malayi
Brugia Timori
Inflammatory Disease
Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis) (see Churg-Strauss Syndrome , [[Churg-Strauss Syndrome]])
Kimura Disease
Neoplastic Disease
Pulmonary Disease
Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis , [[Allergic Bronchopulmonary Aspergillosis]])
Elevated : >1000 IU/mL (International Society for Human and Animal Mycology, ISHAM) (Clin Exp Allergy, 2013) [MEDLINE ]
Generally Higher in ABPA than in Asthma
May Be as High as 25k IU/mL
Serum IgE May Decrease (But Does Not Usually Normalize) Following Glucocorticoid Administration
Asthma (see Asthma , [[Asthma]])
Epidemiology :
Clinical : xxx
Cystic Fibrosis (CF) (see Cystic Fibrosis , [[Cystic Fibrosis]])
Epidemiology : IgE is elevated in 22% of cases
Clinical : xxx
Other
References
Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850 [MEDLINE ]
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