Serum Immunoglobulin E (IgE)

Etiology of Elevated Serum Immunoglobulin E

Atopic Disease


  • Atypical Complete DiGeorge Syndrome
  • Hyper IgE-Recurrent Infection Syndrome (Job’s Syndrome, Buckley-Job Syndrome) (see Hyper IgE-Recurrent Infection Syndrome, [[Hyper IgE-Recurrent Infection Syndrome]])
  • Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX)
  • Netherton Disease
  • Omenn Syndrome
  • Wiskott-Aldrich Syndrome

Infectious Disease

Inflammatory Disease

  • Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis) (see Churg-Strauss Syndrome, [[Churg-Strauss Syndrome]])
  • Kimura Disease

Neoplastic Disease

Pulmonary Disease

  • Allergic Bronchopulmonary Aspergillosis (ABPA) (see Allergic Bronchopulmonary Aspergillosis, [[Allergic Bronchopulmonary Aspergillosis]])
    • Elevated: >1000 IU/mL (International Society for Human and Animal Mycology, ISHAM) (Clin Exp Allergy, 2013) [MEDLINE]
      • Generally Higher in ABPA than in Asthma
      • May Be as High as 25k IU/mL
      • Serum IgE May Decrease (But Does Not Usually Normalize) Following Glucocorticoid Administration
  • Asthma (see Asthma, [[Asthma]])
    • Epidemiology:
    • Clinical: xxx
  • Cystic Fibrosis (CF) (see Cystic Fibrosis, [[Cystic Fibrosis]])
    • Epidemiology: IgE is elevated in 22% of cases
    • Clinical: xxx



  • Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850 [MEDLINE]