Indications

• Evaluation for Acquired Disorders of Fibrinogen
• Evaluation for Disseminated Intravascular Coagulation (DIC) (see Disseminated Intravascular Coagulation, [[Disseminated Intravascular Coagulation]])
• Evaluation for Liver Disease (see End-Stage Liver Disease, [[End-Stage Liver Disease]])
• Evaluation for Primary Hyperfibrinolysis (see Hyperfibrinolytic States, [[Hyperfibrinolytic States]])

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Physiology

• Fibrinogen is the Precursor to Fibrin
  • Fibrinogen Levels are Measured in Plasma: fibrinogen cannot be measured in serum, since it is removed along with the clotted cellular elements

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Etiology of Decreased Plasma Fibrinogen

• Disseminated Intravascular Coagulation (DIC) (see Disseminated Intravascular Coagulation, [[Disseminated Intravascular Coagulation]])
• Liver Disease (see End-Stage Liver Disease, [[End-Stage Liver Disease]])

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Technique

• Normal Fibrinogen Level: >100-150 mg/dL

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References

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