Amitriptyline (Tryptomer, Elavil) (see Amitriptyline, [[Amitriptyline]])
Clomipramine (Anafranil) (see Clomipramine, [[Clomipramine]])
Desipramine (Norpramin, Pertofrane) (see Desipramine, [[Desipramine]])
Doxepin (Adapin, Sinequan) (see Doxepin, [[Doxepin]])
Imipramine (Tofranil, Janimine, Praminil) (see Imipramine, [[Imipramine]])
Nortriptyline (Pamelor, Aventyl, Norpress) (see Nortriptyline, [[Nortriptyline]])
Protriptyline (Vivactil) (see Protriptyline, [[Protriptyline]])
Trimipramine (Surmontil) (see Trimipramine, [[Trimipramine]])
Adverse Effects
Cardiovascular Adverse Effects
QT Prolongation with Variable Association with Torsade (see Torsade, [[Torsade]]): all tricyclic antidepressants cause QT prolongation, but only a few have been definitively associated with torsade
Desipramine (Norpramin, Pertofrane) (see Desipramine, [[Desipramine]])
Doxepin (Adapin, Sinequan) (see Doxepin, [[Doxepin]])
Imipramine (Tofranil, Janimine, Praminil) (see Imipramine, [[Imipramine]])
Neurologic Adverse Effects
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Other Adverse Effects
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Tricyclic Antidepressant (TCA) Intoxication
Epidemiology
Tricyclic overdose is one of the most common drug emergencies in the ED
Higher drug levels correlate with higher risk of pulmonary complications
33% of pulmonary complications in tricyclic overdose are either ALI-ARDS or aspiration pneumonia
80% of cases have widened A-a gradient on presentation