Tretinoin (Vesanoid, All-Trans Retinoic Acid)


Indications

Acute Promyelocytic Leukemia (APML) (see Acute Myeloid Leukemia)

Langerhans Cell Histiocytosis (LCH) (see Langerhans Cell Histiocytosis)


Pharmacology

Binds to Retinoic Acid Receptor-Promyelocytic Leukemia Complex (RAR-PML) Protein

Toxicity

Metabolism


Administration

Oral (PO)

Dose Adjustment

Use in Pregnancy (see Pregnancy)

Use During Breast Feeding


Adverse Effects

Cardiovascular Adverse Effects

Pulmonary Adverse Effects

Retinoic Acid Syndrome

Diffuse Alveolar Hemorrhage (DAH) (see Diffuse Alveolar Hemorrhage)

Renal Adverse Effects

Other Adverse Effects


References