Tobramycin
Pharmacology
- Interference with NMJ transmission
- Hypoventilation leads to hypoxia/acidosis
Adverse Effects
- Aminoglycoside-Related Neuromuscular Toxicity: resembles Botulism
- Predisposing Factors
- Myasthenia Gravis
- ARF/CRF
- Diagnosis
- PFT’s: restriction
- CXR: low lung volumes
- Symptoms: diplopia, dysphagia, dyspnea, dysarthria
- Acute Kidney Injury with ATN (see [[Acute Kidney Injury]]):
Treatment
- Discontinue drug: recovery within hours-days
- Anticholinesterase agents: useful for aminoglycoside neuromuscular toxicity
References
