Indications

• Acute Pulmonary Embolism (see Acute Pulmonary Embolism, [[Acute Pulmonary Embolism]])

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Pharmacology

• Thrombolytic

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Administration

• IV Infusion: 100 mg over 2 hrs
• Bolus Dose (During Code Blue): 0.6 mg/kg over 2 min
• Catheter-Directed Infusion: 50 mg over 2 hrs through peripheral IV or through PA catheter

Subsequent Heparin Administration

• Start heparin drip without bolus when PTT decreases to <2x upper limit of PTT normal range
  • If PTT is >2x, repeat PTT q4 hrs until decreases to <2x upper limit of PTT normal range

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Adverse Effects

• Hemorrhage
• xxx

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References

• xxx