Indications

• Childhood Acute Lymphocytic Leukemia (ALL) (see Acute Lymphocytic Leukemia, [[Acute Lymphocytic Leukemia]])

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Pharmacology

• Podophyllotoxin Agent: inhibition of type II topoisomerase
  • Dose-dependent single and double-stranded DNA breaks in DNA and DNA-protein cross-links
  • Teniposide does not intercalate into DNA or bind avidly to DNA

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Adverse Effects

Pulmonary Adverse Effects

• Hypersensitivity Reaction
  • Epidemiology: occurs in 3.6-6.5% of cases
  • Clinical
    • Bronchospasm (see Obstructive Lung Disease, [[Obstructive Lung Disease]])
    • Dyspnea (see Dyspnea, [[Dyspnea]])
    • Hypertension (see Hypertension, [[Hypertension]])

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References

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