Indications

---

Pharmacology

Tyrosine Kinase Inhibitor

• xxxx

Metabolism

• xxx

---

Administration

• xxxx

Dose Adjustment

• Hepatic:
• Renal:

Use in Pregnancy (see xxxx)

• xxx

Use During Breast Feeding

• xxx

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Adverse Effects

Cardiovascular Adverse Effects

Congestive Heart Failure (CHF) (see Congestive Heart Failure)

• Epidemiology
  • XXXX

QT Prolongation without Definite Association with Torsade (see Torsade)

• Epidemiology
  • XXXX

Pleural and Pericardial Effusion (see xxxx)

• Epidemiology
  • Case Report

Dermatologic Adverse Effects

Chemotherapy-Induced Acral Erythema (Hand-Foot Syndrome, Palmar-Plantar Erythrodysesthesia) (see Chemotherapy-Induced Acral Erythema)

• xxx

Gastrointestinal Adverse Effects

Acalculous Cholecystitis (see Acalculous Cholecystitis)

• xxx

Neurologic Adverse Effects

Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome)

• xxxx

Pulmonary Adverse Effects

Acute Pneumonitis (see Pneumonia)

• Epidemiology
  • XXXX

Diffuse Alveolar Hemorrhage (DAH) (see Diffuse Alveolar Hemorrhage)

• Epidemiology
  • Case Report

Interstitial Pneumonia (see Interstitial Lung Disease)

• Epidemiology
  • XXXX

Pleural and Pericardial Effusion (see xxxx)

• Epidemiology
  • Case Report

Other Adverse Effects

• xxx
• xxx
• xxx

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References

• Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15;370(9604):2011-9 [MEDLINE]
• Acute cardiac failure after sunitinib. Ann Oncol. 2008 Mar;19(3):597-9. doi: 10.1093/annonc/mdn019. Epub 2008 Feb 13 [MEDLINE]
• Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. Ann Oncol. 2008 Sep;19(9):1613-8. doi: 10.1093/annonc/mdn168. Epub 2008 Apr 23 [MEDLINE]
• Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib. Int J Clin Oncol. 2010 Dec;15(6):638-41. doi: 10.1007/s10147-010-0104-3. Epub 2010 Jul 3 [MEDLINE]
• Targeted therapies: Risk of heart failure with sunitinib. Nat Rev Clin Oncol. 2011 Aug 16;8(10):569. doi: 10.1038/nrclinonc.2011.129 [MEDLINE]
• Lung toxicity in a patient treated with sunitinib. Eur Respir J. 2012 Nov;40(5):1300-3. doi: 10.1183/09031936.00048212 [MEDLINE]
• Sunitinib-related interstitial pneumonia after treatment with temsirolimus: a case of possible recall phenomenon. Int J Urol. 2014 Apr;21(4):420-1. doi: 10.1111/iju.12332. Epub 2013 Oct 29 [MEDLINE]
• Interstitial lung disease during targeted therapy in metastatic renal cell carcinoma: a case series from three centres. Med Oncol. 2014 Sep;31(9):147. doi: 10.1007/s12032-014-0147-9. Epub 2014 Aug 15 [MEDLINE]
• Intolerance to sunitinib treatment in hemodialysis patients with metastatic renal cell carcinoma. Korean J Urol. 2014 Jan;55(1):74-6. doi: 10.4111/kju.2014.55.1.74. Epub 2014 Jan 15 [MEDLINE]
• Pleural and pericardial effusions combined with ascites in a patient with severe sunitinib-induced hypothyroidism. Acta Clin Belg. 2016 Jun;71(3):175-7. doi: 10.1179/2295333715Y.0000000065. Epub 2016 Feb 7 [MEDLINE]