MD Nexus

Sulfonylureas

Agents

First Generation Sulfonylureas

Acetohexamide
Carbutamide
Chlorpropamide (see Chlorpropamide)
Tolbutamide (see Tolbutamide)

Second Generation Sulfonylureas

Glibornuride
Gliclazide
Glimepiride (Amaryl) (see Glimepiride)
Glipizide (Glucotrol) (see Glipizide)
Gliquidone
Glisoxepide
Glyburide (Diabeta, Glynase, Micronase, Glibenclamide) (see Glyburide)
Glyclopyramide (Deamelin-S)

Adverse Effects

Gastrointestinal Adverse Effects

Asymptomatic Elevation of Hepatic Transaminases (Isolated Transaminitis) (see Drug-Induced Hepatotoxicity)

References

Comparative Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas in Patients With Type 2 Diabetes. JAMA Intern Med. 2021 Aug 1;181(8):1043-1053. doi: 10.1001/jamainternmed.2021.2488 [MEDLINE]