Rimantadine (Flumadine)
Indications
Influenza Treatment (see Influenza Virus, [[Influenza Virus]])
- Indications: patients >13 y/o
- Clinical Efficacy
- Early treatment (within 48 hrs) is probably better than later treatment
- Probably decreases the duration of fever and symptoms by 1-2 days
Influenza Prophylaxis (see Influenza Virus, [[Influenza Virus]])
- Indications: patients >1 y/o
- Clinical Efficacy
- Given x 2 wks during epidemic, during which vaccine will induce Ab response
- Given during facility outbreak, to all exposed regardless of vaccination status, until 1 wk after end of outbreak
Contraindications
Pharmacology
- M2 Ion Channel Blocker (Adamantane)
- Metabolism: hepatic clearance
Administration
- PO: xxx
- Hepatic Dose Adjustment: xxx
- Renal Dose Adjustment: xxx
Adverse Effects
- Mild Central Nervous System Effects: insominia, anxiety, or difficulty concentrating occur in 6% of cases
- Seizures (see Seizures, [[Seizures]]): usually in those with history of seizures
- Delirium (see Delirium, [[Delirium]]): usually in those with psychiatric history
References