Indications

Influenza Treatment (see Influenza Virus, [[Influenza Virus]])

• Indications: patients >13 y/o
• Clinical Efficacy
  • Early treatment (within 48 hrs) is probably better than later treatment
  • Probably decreases the duration of fever and symptoms by 1-2 days

Influenza Prophylaxis (see Influenza Virus, [[Influenza Virus]])

• Indications: patients >1 y/o
• Clinical Efficacy
  • Given x 2 wks during epidemic, during which vaccine will induce Ab response
  • Given during facility outbreak, to all exposed regardless of vaccination status, until 1 wk after end of outbreak

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Contraindications

• Pregnancy (see Pregnancy, [[Pregnancy]])

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Pharmacology

• M2 Ion Channel Blocker (Adamantane)
  • Activity: Influenza A
• Metabolism: hepatic clearance

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Administration

• PO: xxx
• Hepatic Dose Adjustment: xxx
• Renal Dose Adjustment: xxx

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Adverse Effects

• Mild Central Nervous System Effects: insominia, anxiety, or difficulty concentrating occur in 6% of cases
• Seizures (see Seizures, [[Seizures]]): usually in those with history of seizures
• Delirium (see Delirium, [[Delirium]]): usually in those with psychiatric history

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References

• xxx