Epidemiology

• Indications
  • Hodgkin’s Disease
  • Lymphoproliferative Disorders
  • Glioblastoma Multiforme

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Pharmacology

• Alkylating Agent: likely cytotoxic effect

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Adverse Effects

• Acute or Subacute Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology)
  • Epidemiology: few case reports
  • Onset: within hours after dose
• Pulmonary Infiltrates with Eosinophilia (see Drug-Induced Pulmonary Eosinophilia)
• Pleural Effusion (see Pleural Effusion-Exudate)

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Treatment

• Withdraw drug -> resolves rapidly

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References

• Procarbazine-induced interstitial pneumonitis with a normal chest x-ray: a case report. Med Pediatr Oncol. 1986;14(4):238-41