Indications
Pharmacology
- Polymyxin Antibiotic (see Polymyxins, [[Polymyxins]])
Administration
- IV:
- Topical:
- Subconjunctival:
Adverse Effects
- Neuromuscular Junction Antagonism with Respiratory Muscle Weakness (see Acute Hypoventilation, [[Acute Hypoventilation]] and Chronic Hypoventilation, [[Chronic Hypoventilation]])
- Risk Factors for Neuromuscular Junction Antagonism
- Intraperitoneal Adminsistration
- Intrapleural Administartion
- Chronic Kidney Disease (CKD)
- Associated Use of Paralytics
- Treatment: may respond to physostigmine
Renal Adverse Effects
References
- Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother. 2012 Sep;56(9):4625-9 [MEDLINE]
- Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics. Future Microbiol. 2013 Jun;8(6):711-24 [MEDLINE]
- Higher Incidence of Acute Kidney Injury With Intravenous Colistimethate Sodium Compared With Polymyxin B in Critically Ill Patients at a Tertiary Care Medical Center. Clin Infect Dis. 2013 Nov;57(9):1300-1303 [MEDLINE]