Epidemiology

• Indications
  • Parasitic Infections
  • Transitional Cell Cancer
  • Psoriasis

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Pharmacology

• Dihydrofolate Reductase Inhibitor (closely related to methotrexate)

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Adeverse Effects

• Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology)
  • Epidemiology: occurs in 14% of cases
  • Treatment: withdrawal of drug

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References

• Piritrexim-induced pulmonary toxicity. Am J Clin Oncol. 1993 Apr;16(2):146-8