Indications

Diaphoresis/Hypertension in the Setting of Pheochromocytoma (see Hypertension, [[Hypertension]] and Pheochromocytoma, [[Pheochromocytoma]])

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Pharmacology

• α-Adrenergic Receptor Antagonist (Non-Selective) (see α-Adrenergic Receptor Antagonists, [[α-Adrenergic Receptor Antagonists]])

Metabolism

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Administration

• PO (Essential Hypertension): start 0.25-1 mg/kg/day, increase slowly to achieve blood pressure control
• PO (Pheochromocytoma): start 10 mg PO BID, increase slowly every other day until blood pressure is controlled
  • Typical Dose: 20-40 mg BID-TID
  • Max Dose (Reported): 240 mg/day

Dose Adjustment

• Hepatic: none
• Renal: none (use with caution)

Drug Interaction

• Drugs Which Stimulate Both α-Adrenergic and β-Adrenergic Receptors: concomitant use may precipitate the hypotensive effect of phenoxybenzamine

Use in Pregnancy (see Pregnancy, [[Pregnancy]])

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Use in Lactation

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Adverse Effects

Cardiovascular Adverse Effects

• Orthostatic Hypotension (see Hypotension, [[Hypotension]])
• Tachycardia (see Sinus Tachycardia, [[Sinus Tachycardia]])

Gastrointestinal Adverse Effects

• Gastrointestinal Irritation

Neurologic Adverse Effects

• Drowsiness/Fatigue (see Fatigue, [[Fatigue]])

Ophthalmologic Adverse Effects

• Miosis (see xxxx, [[xxxx]])

Otolaryngologic Adverse Effects

• Nasal Congestion

Other Adverse Effects

• Inhibited Ejaculation

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References

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