Indications

• Pneumocystis Jirovecii (see Pneumocystis Jirovecii, [[Pneumocystis Jirovecii]])
  • Prophylaxis
  • Treatment

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Pharmacology

• xxx
• Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): inhibits sodium channels on the luminal membrane of cells in the renal collecting tubule
  • Collecting tubule is the site of action of aldosterone

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Administration

• INH (Prophylaxis)
• IV (Treatment)

Dose Adjustment

• Hepatic
• Renal

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Adverse Effects

Cardiovascular Adverse Effects

• Q-T Prolongation with Definite Association with Torsade (see Torsade, [[Torsade]])

Endocrinologic Adverse Effects

• xxx (see xxxx, [[xxxx]])

Gastrointestinal Adverse Effects

• Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]]): definite association with acute pancreatitis

Pulmonary Adverse Effects

• Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]]): reported with inhaled pentamidine

Renal Adverse Effects

Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])

• Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
• Clinical
  • Hyperkalemia (see Hyperkalemia, [[Hyperkalemia]])

Other Adverse Effects

• xxx

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References

• xxx