Indications
Pharmacology
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- Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): inhibits sodium channels on the luminal membrane of cells in the renal collecting tubule
- Collecting tubule is the site of action of aldosterone
Administration
- INH (Prophylaxis)
- IV (Treatment)
Dose Adjustment
Adverse Effects
Cardiovascular Adverse Effects
- Q-T Prolongation with Definite Association with Torsade (see Torsade, [[Torsade]])
Endocrinologic Adverse Effects
Gastrointestinal Adverse Effects
- Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]]): definite association with acute pancreatitis
Pulmonary Adverse Effects
Renal Adverse Effects
Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])
- Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
- Clinical
Other Adverse Effects
References