Pentamidine (Nebupent)

Indications

Pneumocystis Jirovecii (see Pneumocystis Jirovecii, [[Pneumocystis Jirovecii]])
- Prophylaxis
- Treatment

Pharmacology

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Epithelial Sodium Channel (ENaC) Antagonist (see Epithelial Sodium Channel Antagonists, [[Epithelial Sodium Channel Antagonists]]): inhibits sodium channels on the luminal membrane of cells in the renal collecting tubule
- Collecting tubule is the site of action of aldosterone

Administration

INH (Prophylaxis)
IV (Treatment)

Dose Adjustment

Hepatic
Renal

Adverse Effects

Cardiovascular Adverse Effects

Q-T Prolongation with Definite Association with Torsade (see Torsade, [[Torsade]])

Endocrinologic Adverse Effects

xxx (see xxxx, [[xxxx]])

Gastrointestinal Adverse Effects

Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]]): definite association with acute pancreatitis

Pulmonary Adverse Effects

Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]]): reported with inhaled pentamidine

Renal Adverse Effects

Hypoaldosteronism (see Hypoaldosteronism, [[Hypoaldosteronism]])

Physiology: due to epithelial sodium channel (ENaC) antagonism in renal collecting tubule
Clinical
- Hyperkalemia (see Hyperkalemia, [[Hyperkalemia]])

Other Adverse Effects

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References

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