Pantoprazole (Protonix)


Peptic Ulcer Disease (PUD) (see Peptic Ulcer Disease, [[Peptic Ulcer Disease]])

  • Treatment
  • Prophylaxis



  • xxx


  • PO
  • IV

Dose Adjustment

  • Hepatic
  • Renal

Drug Interactions

  • Methotrexate (see Methotrexate, [[Methotrexate]])
    • Proton Pump Inhibitors Impair Urinary Clearance of Methotrexate and Increase the Risk of Renal Toxicity: the mechanism is unclear -> proton pump inhibitors should be discontinued prior to methotrexate administration

Adverse Effects

Other Adverse Effects

  • xxx


  • Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009;67:44–49 [MEDLINE]

  • Delayed elimination of methotrexate associated with co-administration of proton pump inhibitors. Anticancer Res.  2010;30:3807–3810 [MEDLINE]

  • Accumulating evidence for a drug-drug interaction between methotrexate and proton pump inhibitors. The Oncologist.  2012;17:550–555 [MEDLINE]

  • Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma.  Leuk Lymphoma.  2012;53:1867–1875 [MEDLINE]