Oxybutynin (Ditropan)


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Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Neurologic Adverse Effects

Increased Risk of Dementia (with Chronic Anti-Cholinergic Use)

  • Epidemiology: anticholinergic-induced cognitive impairment is generally considered reversible on discontinuation of anticholinergic therapy
    • However, studies suggest that anticholinergic agents may be associated with an increased risk for dementia
  • Prospective Cohort Study (JAMA Int Med, 2015) [MEDLINE]: higher cumulative anticholinergic use (most commonly tricyclic antidepressants, first-generation antihistamines, and bladder anti-muscarinics) was associated with an increased risk for dementia

Toxicologic Adverse Effects

Other Adverse Effects

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  • Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175:401-407 [MEDLINE]