Indications
- Colon Cancer (see Colon Cancer, [[Colon Cancer]])
Pharmacology
- Alkylating Agent
Adverse Effects
Allergic/Immunologic Adverse Effects
- Cytokine Release Syndrome (see Cytokine Release Syndrome, [[Cytokine Release Syndrome]])
- Severe Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]]): occurs in 1.3% of cases
Neurologic Adverse Effects
- Ototoxicity: rare with oxaliplatin (in contrast to cisplatin)
- Peripheral Neuropathy (see Peripheral Neuropathy, [[Peripheral Neuropathy]])
- Acute Neurotoxicity: likely due to calcium chelation by oxalate (a metabolite of oxaliplatin) -> activation of disinhibited peripheral nerve voltage-gated calcium-dependent sodium channels and disruption in cell membrane ion channels, resulting in hyperexcitability of peripheral nerves
- Cold-Induced Peri-Oral Parasthesias
- Cold-Induced Pharyngolaryngeal Dysesthesia (“Pseudolaryngospasm”)
- Dysphagia (see Dysphagia, [[Dysphagia]])
- Dyspnea (see Dyspnea, [[Dyspnea]])
- Fasciculations (see Fasciculations, [[Fasciculations]])
- Jaw Stiffness
- Muscle Cramps
- Ocular Changes
- Voice Changes
- Cumulative Sensory Neuropathy
- Acute Neurotoxicity: likely due to calcium chelation by oxalate (a metabolite of oxaliplatin) -> activation of disinhibited peripheral nerve voltage-gated calcium-dependent sodium channels and disruption in cell membrane ion channels, resulting in hyperexcitability of peripheral nerves
- Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome, [[Posterior Reversible Encephalopathy Syndrome]])
Pulmonary Adverse Effects
- Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]]): diffuse alveolar damage has been reported to occur in combination with 5-fluorouracil (see 5-Fluorouracil, [[5-Fluorouracil]])
- Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])
Other Adverse Effects
- xxx
References
- Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients. Journal of Biological Regulators and Homeostatic Agents 2002, 16(2):105-9 [MEDLINE]