Oxaliplatin (Eloxatin, Oxaliplatin Medac)



  • Alkylating Agent

Adverse Effects

Allergic/Immunologic Adverse Effects

Neurologic Adverse Effects

  • Ototoxicity: rare with oxaliplatin (in contrast to cisplatin)
  • Peripheral Neuropathy (see Peripheral Neuropathy, [[Peripheral Neuropathy]])
    • Acute Neurotoxicity: likely due to calcium chelation by oxalate (a metabolite of oxaliplatin) -> activation of disinhibited peripheral nerve voltage-gated calcium-dependent sodium channels and disruption in cell membrane ion channels, resulting in hyperexcitability of peripheral nerves
      • Cold-Induced Peri-Oral Parasthesias
      • Cold-Induced Pharyngolaryngeal Dysesthesia (“Pseudolaryngospasm”)
      • Dysphagia (see Dysphagia, [[Dysphagia]])
      • Dyspnea (see Dyspnea, [[Dyspnea]])
      • Fasciculations (see Fasciculations, [[Fasciculations]])
      • Jaw Stiffness
      • Muscle Cramps
      • Ocular Changes
      • Voice Changes
    • Cumulative Sensory Neuropathy
  • Posterior Reversible Encephalopathy Syndrome (PRES) (see Posterior Reversible Encephalopathy Syndrome, [[Posterior Reversible Encephalopathy Syndrome]])

Pulmonary Adverse Effects

Other Adverse Effects

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  • Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients. Journal of Biological Regulators and Homeostatic Agents 2002, 16(2):105-9 [MEDLINE]