Omega-3 Fatty Acid (Fish Oil, Lovaza)
Indications
Hypertriglyceridemia (see Hypertriglyceridemia , [[Hypertriglyceridemia]]): indicated for severe hypertriglyceridemia (triglycerides >500 mg/dL)
Pharmacology
Ethyl Esters of Omega-3 Fatty Acids (EPA + DHA) : fish sources
Metabolism
Administration
PO : 2 g BID (or 4 g qday)
Cautions
Fish/Shellfish Allergy : use with caution
Dose Adjustment
Adverse Effects
Allergic Adverse Effects
Cardiovascular Adverse Effects
Possibly Increased Risk of Recurrence of Atrial Fibrillation/Flutter in Patients with Paroxysmal or Persistent Atrial Fibrillation (see Atrial Fibrillation , [[Atrial Fibrillation]] and Atrial Flutter , [[Atrial Flutter]]): especially in the first 2-3 mo of therapy
Dermatologic Adverse Effects
Pruritus (see Pruritus , [[Pruritus]])
Rash
Gastrointestinal/Hepatic Adverse Effects
Constipation
Dyspepsia
Elevated LFT’s/Transaminitis
Eructation
Taste Changes
Vomiting (see Nausea and Vomiting , [[Nausea and Vomiting]])
Hematologic Adverse Effects
Platelet Dysfunction (see Coagulopathy , [[Coagulopathy]]): due to impaired platelet aggregation
Other Adverse Effects
References
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