Trial of Omalizumab for Asthma in Inner-City Children (NEJM, 2011) [MEDLINE]: omalizumab added to standard asthma therapy in inner-city children/adolescents/young adults
Omalizumab Decreased the Number of Days with Asthma Symptoms
Omalizumab Decreased Asthma Exacerbations: nearly eliminating seasonal peaks in exacerbations
Omalizumab Decreased the Need for Other Medications to Control Asthma
Cochrane Database Systematic Review Examining Omalizumab in Adults/Children with Asthma (2014) [MEDLINE]
As Adjunct to Inhaled Corticosteroids (and During Corticosteroid Tapering), Omalizumab Decreased Asthma Exacerbations/Hospitalizations
Omalizumab was Effective in Allowing Corticosteroid Taper/Withdrwal
Unclear Whether There is a Threshold Level of Serum IgE Which Predicts Optimal Efficacy of Omalizumab
Pharmacology
Anti-IgE
Metabolism
xxx
Administration
xxxx: xxx
Dose Adjustment
Hepatic
Renal
Adverse Effects
xxx
xxx
Other Adverse Effects
Injection Site Reaction
References
Randomized trial of omalizumab (Anti-IgE) for asthma in inner-city children. N Engl J Med 2011;364:1005-1015 [MEDLINE]
Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy. Ann Intern Med 2011;154:573-582 [MEDLINE]
Omalizumab for asthma in adults and children. Cochrane Database Syst Rev. 2014 Jan 13;1:CD003559. doi: 10.1002/14651858.CD003559.pub4 [MEDLINE]
