Agents

• Bendamustine (Treakisym, Ribomustin, Levact, Treanda, SDX-105) (see Bendamustine, [[Bendamustine]])
• Carmustine (BCNU) (see Carmustine, [[Carmustine]])
• Chlorozotocin (see Chlorozotocin, [[Chlorozotocin]])
• Ethylnitrosourea (ENU)
• Fotemustine (see Fotemustine, [[Fotemustine]])
• Lomustine (CCNU) (see Lomustine, [[Lomustine]])
• Semustine (methyl-CCNU) (see Semustine, [[Semustine]])
• Streptozotocin

Pharmacology

• DNA Alkylating Agents: attaches an alkyl group (CnH2n+1) to guanine base of DNA, at the number 7 nitrogen atom of the purine ring
• Lipophilic : able to cross the blood-brain barrier
  • Useful in treatment of glioblastoma multiforme (see Glioblastoma Multiforme, [[Glioblastoma Multiforme]])

References

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