Indications

• Acute Coronary Syndrome/Angina (see Coronary Artery Disease, [[Coronary Artery Disease]])
• Hypertension (see Hypertension, [[Hypertension]])
• Cardiogenic Pulmonary Edema (see Pulmonary Edema, [[Pulmonary Edema]])

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Pharmacology

• Nitrate (see Nitrites and Nitrates, [[Nitrites and Nitrates]])
• Actions on Pulmonary Vascular Tone

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Administration

• IV (Nitroglycerin Drip):
• TOP (Nitropaste): 1-2 in q6hrs
• TOP (Nitropatch)

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Adverse Effects

Cardiovascular Adverse Effects

• Hypotension (see Hypotension, [[Hypotension]])

Neurologic Adverse Effects

• Headache (see Headache, [[Headache]])

Pulmonary Adverse Effects

• Hypoxemia (see Hypoxemia, [[Hypoxemia]]): due to direct action on pulmonary vascular tone, altering V/Q relationships
  • May exacerbate hypoxemia (particularly in ALI/ARDS)

Toxicologic Adverse Effects

• Methemoglobinemia (see Methemoglobinemia, [[Methemoglobinemia]])

Other Adverse Effects

• xxxx

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References

• xxx