Neuromuscular Junction Antagonists

Indications

  • Need for Procedural/Operative Paralysis
  • Need for Sedation to Facilitate Mechanical Ventilation in Acute Respiratory Distress Syndrome (ARDS) (see Acute Respiratory Distress Syndrome, [[Acute Respiratory Distress Syndrome]])
  • Rapid Sequence Intubation (RSI) (see Airway Management, [[Airway Management]])

Agents

Benzylisoquinolines

  • Alcuronium
  • Atracurium (Tracrium) (see Atracurium)
  • Cisatracurium (Nimbex) (see Cisatracurium)
  • Doxacurium (Nuromax))
  • Mivacurium
  • Tubocurarine

Aminosteroids

  • Pancuronium (Pavulon) (see Pancuronium)
  • Pipecuronium (Arduan)
  • Rapacuronium
  • Rocuronium (Zemuron, Esmeron) (see Rocuronium)
  • Vecuronium (Norcuron) (see Vecuronium)

Depolarizing

NMJ ANTAGONISTS

References

  • Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient. Crit Care Med. 2002;30:142-158
  • Elimination of atracurium in humans: contribution of Hofmann elimination and ester hydrolysis versus organ-based elimination. Anesthesiology. 1986;65:6-12