Indications

• Pain

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Pharmacology

• Non-Steroidal Anti-Inflammatory Drug (NSAID) (see Non-Steroidal Anti-Inflammatory Drug, [[Non-Steroidal Anti-Inflammatory Drug]])

Metabolism

• xxx

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Administration

• PO: xxx

Dose Adjustment

• Hepatic
• Renal

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Adverse Effects

Gastrointestinal/Hepatic Manifestations

• Fulminant Hepatic Failure with Massive Hepatic Necrosis (see Fulminant Hepatic Failure, [[Fulminant Hepatic Failure]])

Pulmonary Adverse Effects

• Exacerbation of Asthma (see Asthma, [[Asthma]])
  • See Acetylsalicylic Acid, [[Acetylsalicylic Acid]]
• Salicylate Intoxication-Associated Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
  • See Acetylsalicylic Acid, [[Acetylsalicylic Acid]]
• Pulmonary Infiltrates with Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])
  • Epidemiology: appears to be more frequent with naproxen than other NSAID’s
  • See Acetylsalicylic Acid, [[Acetylsalicylic Acid]]

Renal Adverse Effects

• Acute Kidney Injury (see Acute Kidney Injury, [[Acute Kidney Injury]])
• Increased Sodium Reabsorption with Peripheral Edema
  • See Non-Steroidal Anti-Inflammatory Drug, [[Non-Steroidal Anti-Inflammatory Drug]])
• Hyperkalemia (see Hyperkalemia, [[Hyperkalemia]])

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References

• xxx