Moxifloxacin (Avelox, Avalox, Avelon)
Pharmacology
Adverse Effects
Cardiac Adverse Effects
- Q-T Prolongation/Torsade (see Torsade, [[Torsade]])
- Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
- Risk of Q-T Prolongation (in descending order or probability)
- High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
- Medium: Gemifloxacin, Levofloxacin, Ofloxacin
- Low: Ciprofloxacin
- Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small
Orthopedic Adverse Effects
- Tendinitis/Tendon Rupture (see xxx)
Other Adverse Effects
References