Indications

• Candidemia (see Candida, [[Candida]])
• Candida Esophagitis (see Candida, [[Candida]])
• Candida Peritonitis/Abscess (see Candida, [[Candida]])
• Candida Prophylaxis (see Candida, [[Candida]])

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Pharmacology

• Echinocandin (see Echinocandins, [[Echinocandins]])
  • Concentration-dependent inhibition of 1,3-beta-D-glucan synthase -> decreased synthesis of 1,3-beta-D-glucan (an essential polysaccharide in the Candida cell wall) -> osmotic instability -> cellular lysis
• Origin/Synthesis: micafungin is a natural antifungal derived from the lipopeptide FR901379, isolated from the Coleophoma empetri fungus
• Metabolism: hepatic

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Administration

• IV (Candidemia/Candida Peritonitis/Candida Abscess): 100 mg qday
• IV (Candida Esophagitis): 150 mg qday
• IV (Candida Prophylaxis): 50 mg qday

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Adverse Effects

Gastrointestinal Adverse Effects

• Abdominal Pain (see Abdominal Pain, [[Abdominal Pain]])
• Diarrhea (see Diarrhea, [[Diarrhea]])
• Elevated LFT’s (see xxxx, [[]])
• Nausea/Vomiting (see Nausea and Vomiting, [[Nausea and Vomiting]])

Hematologic Adverse Effects

• Leukopenia/Neutropenia (see Leukopenia, [[Leukopenia]])
• Thrombocytopenia (see Thrombocytopenia, [[Thrombocytopenia]])

Other Adverse Effects

• Headache (see Headache, [[Headache]])
• Rash/Pruritus

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References

• xxx