Micafungin (Mycamine)
Indications
- Candidemia (see Candida, [[Candida]])
- Candida Esophagitis (see Candida, [[Candida]])
- Candida Peritonitis/Abscess (see Candida, [[Candida]])
- Candida Prophylaxis (see Candida, [[Candida]])
Pharmacology
- Echinocandin (see Echinocandins, [[Echinocandins]])
- Concentration-dependent inhibition of 1,3-beta-D-glucan synthase -> decreased synthesis of 1,3-beta-D-glucan (an essential polysaccharide in the Candida cell wall) -> osmotic instability -> cellular lysis
- Origin/Synthesis: micafungin is a natural antifungal derived from the lipopeptide FR901379, isolated from the Coleophoma empetri fungus
- Metabolism: hepatic
Administration
- IV (Candidemia/Candida Peritonitis/Candida Abscess): 100 mg qday
- IV (Candida Esophagitis): 150 mg qday
- IV (Candida Prophylaxis): 50 mg qday
Adverse Effects
Gastrointestinal Adverse Effects
Hematologic Adverse Effects
Other Adverse Effects
- Headache (see Headache, [[Headache]])
- Rash/Pruritus
References