MD Nexus

Micafungin (Mycamine)

Indications

Candida (see Candida)

Candidemia (see Candida)
Candida Esophagitis (see Candida)
Candida Peritonitis/Abscess (see Candida)
Candida Prophylaxis (see Candida)

Pharmacology

Origin/Synthesis: micafungin is a natural antifungal derived from the lipopeptide FR901379, isolated from the Coleophoma empetri fungus
Echinocandin (see Echinocandins)
- Inhibition of Formation of ß-Glucans in Fungal Cell Wall: ß-glucans are not present in the mammalian cell wall
  - Candida (see Candida): cidal for all species
  - Aspergillus (see Aspergillus): probably also cidal for all species
  - Cryptococcus (see Cryptococcosis): not active

Metabolism

Hepatic

Administration

IV (Candidemia/Candida Peritonitis/Candida Abscess): 100 mg qday
IV (Candida Esophagitis): 150 mg qday
IV (Candida Prophylaxis): 50 mg qday

Dose Adjustment

Hepatic
Renal

Use in Pregnancy (see Pregnancy)

xxx

Use During Breast Feeding

xxx

Adverse Effects

Dermatologic Adverse Effects

Rash/Pruritus (see Pruritus)

Epidemiology
- XXXX

Gastrointestinal Adverse Effects

Abdominal Pain (see Abdominal Pain)

Epidemiology
- XXXX

Diarrhea (see Diarrhea)

Epidemiology
- XXXX

Elevated Liver Function Tests (LFT’s)(see Elevated Liver Function Tests)

Epidemiology
- XXXX
Clinical
- XXXX

Nausea/Vomiting (see Nausea and Vomiting)

Epidemiology
- XXXX

Hematologic Adverse Effects

Leukopenia/Neutropenia (see Leukopenia)

Epidemiology
- XXXX

Thrombocytopenia (see Thrombocytopenia)

Epidemiology
- XXXX

Neurologic Adverse Effects

Headache (see Headache)

Epidemiology
- XXXX

References

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug 15;63(4):e1-e60. doi: 10.1093/cid/ciw326. Epub 2016 Jun 29 [MEDLINE]