Micafungin (Mycamine)

Indications

Candidemia (see Candida, [[Candida]])
Candida Esophagitis (see Candida, [[Candida]])
Candida Peritonitis/Abscess (see Candida, [[Candida]])
Candida Prophylaxis (see Candida, [[Candida]])

Pharmacology

Echinocandin (see Echinocandins, [[Echinocandins]])
- Concentration-dependent inhibition of 1,3-beta-D-glucan synthase -> decreased synthesis of 1,3-beta-D-glucan (an essential polysaccharide in the Candida cell wall) -> osmotic instability -> cellular lysis
Origin/Synthesis: micafungin is a natural antifungal derived from the lipopeptide FR901379, isolated from the Coleophoma empetri fungus
Metabolism: hepatic

Administration

IV (Candidemia/Candida Peritonitis/Candida Abscess): 100 mg qday
IV (Candida Esophagitis): 150 mg qday
IV (Candida Prophylaxis): 50 mg qday

Adverse Effects

Gastrointestinal Adverse Effects

Abdominal Pain (see Abdominal Pain, [[Abdominal Pain]])
Diarrhea (see Diarrhea, [[Diarrhea]])
Elevated LFT’s (see xxxx, [[]])
Nausea/Vomiting (see Nausea and Vomiting, [[Nausea and Vomiting]])

Hematologic Adverse Effects

Leukopenia/Neutropenia (see Leukopenia, [[Leukopenia]])
Thrombocytopenia (see Thrombocytopenia, [[Thrombocytopenia]])

Other Adverse Effects

Headache (see Headache, [[Headache]])
Rash/Pruritus

References

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