Epidemiology

• Topical Antibiotic Used in Burn Patients to Prevent Bacterial Colonization Prior to Skin Grafting (see Burns, [[Burns]])
  • Mafenide is Rapidly Absorbed Systemically

---

Pharmacology

• Sulfonamide Antibiotic with Carbonic Anhydrase Inhibition Properties (see Sulfonamides, [[Sulfonamides]]): some of its metabolites also have carbonic anhydrase inhibition properties
  • Renal Bicarbonate Loss: bicarbonate is replaced by chloride (produces hyperchloremia)

Metabolism

• xxx

---

Administration

• TOPICAL: xxx

Dose Adjustment

• Hepatic
• Renal

---

Adverse Effects

Renal Adverse Effects

• Type 2 Proximal Renal Tubular Acidosis with Non-Anion Gap Metabolic Acidosis (NAGMA) (see Type 2 Proximal Renal Tubular Acidosis, [[Type 2 Proximal Renal Tubular Acidosis]]) and Metabolic Acidosis-Normal Anion Gap, [[Metabolic Acidosis-Normal Anion Gap]])

Other Adverse Effects

• xxx

---

References

• xxx