Indications

• xxx

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Pharmacology

• Fluoroquinolone Antibiotic (see Fluoroquinolones, [[Fluoroquinolones]])

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Administration

• PO:
• IV:

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Adverse Effects

Pulmonary Adverse Effects

• Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])

Cardiac Adverse Effects

• Q-T Prolongation (see Torsade, [[Torsade]])
• Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
  • Risk of Q-T Prolongation (in descending order or probability)
    • High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
    • Medium: Gemifloxacin, Levofloxacin, Ofloxacin
    • Low: Ciprofloxacin
  • Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small

Hematologic Adverse Effects

• Hemolytic Anemia (see Hemolytic Anemia, [[Hemolytic Anemia]])

Orthopedic Adverse Effects

• Tendinitis/Tendon Rupture (see Tendon Rupture, [[Tendon Rupture]])

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References

• Levofloxacin-induced autoimmune hemolytic anemia. Ann Pharmacother. 2003 Jul-Aug;37(7-8):1010-3 [MEDLINE]