Indications
- xxx
Pharmacology
- Fluoroquinolone Antibiotic (see Fluoroquinolones, [[Fluoroquinolones]])
Administration
- PO:
- IV:
Adverse Effects
Pulmonary Adverse Effects
- Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])
Cardiac Adverse Effects
- Q-T Prolongation (see Torsade, [[Torsade]])
- Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
- Risk of Q-T Prolongation (in descending order or probability)
- High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
- Medium: Gemifloxacin, Levofloxacin, Ofloxacin
- Low: Ciprofloxacin
- Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small
- Risk of Q-T Prolongation (in descending order or probability)
Hematologic Adverse Effects
- Hemolytic Anemia (see Hemolytic Anemia, [[Hemolytic Anemia]])
Orthopedic Adverse Effects
- Tendinitis/Tendon Rupture (see Tendon Rupture, [[Tendon Rupture]])
References
- Levofloxacin-induced autoimmune hemolytic anemia. Ann Pharmacother. 2003 Jul-Aug;37(7-8):1010-3 [MEDLINE]