Leuprolide (Lupron)



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Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Pulmonary Adverse Effects

Interstitial Pneumonits (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])

  • Epidemiology: reported in patients treated with combination therapies for prostate cancer
    • Leuprolide + Bicalutamide (see Bicalutamide, [[Bicalutamide]])
    • Leuprolide + Flutamide (see Flutamide, [[Flutamide]])
    • Leuprolide + Nilutamide (see Nilutamide, [[Nilutamide]])

Other Adverse Effects

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  • Interstitial pneumonitis associated with neoadjuvant leuprolide and nilutamide for prostate cancer. J Urol. 1998 Jun;159(6):2099 [MEDLINE]
  • Interstitial pneumonitis related to leuprorelin acetate and flutamide. J Urol. 1999 Jan;161(1):221 [MEDLINE]
  • Interstitial pneumonitis induced by bicalutamide and leuprorelin acetate for prostate cancer. Int J Urol. 2003 Nov;10(11):625-6 [MEDLINE]