Indications

• Chronic Stable Congestive Heart Failure (CHF) with Ejection Fraction 35% or Lower and Relative Tachycardia (HR >70) Despite Beta Blockade (or in Presence of Contraindication for Beta Blockade) (see Congestive Heart Failure, [[Congestive Heart Failure]]): FDA-approved 4/15/15 (via fast-track process)
  • Decreases Hospitalizations for Congestive Heart Failure

---

Pharmacology

• Inhibitor of If (I”funny”) Current in SA Node

Metabolism

• xxx

---

Administration

• xxx

Dose Adjustment

• Hepatic: xxx
• Renal: xxx

---

Adverse Effects

Cardiovascular Adverse Effects

• Atrial Fibrillation (AF) (see Atrial Fibrillation, [[Atrial Fibrillation]])
• Bradycardia (see Bradycardia, [[Bradycardia]])

Renal Adverse Effects

• Hypertension (see Hypertension, [[Hypertension]])

Other Adverse Effects

• Luminous Phenomena/Visual Brightness

---

References

• xxx