Epidemiology

• Indications
  • Lung Cancer
  • Breast Cancer
  • Testicular Cancer

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Pharmacology

• Alkylating Agent

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Adverse Effects

Pulmonary Adverse Effects

• Subacute Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology)
  • Unclear role of ifosfamide, as other chemo agents (including docetaxel) were used concurrently
  • One case of fatal pneumonitis has been reported

Other Adverse Effects

• Methemoglobinemia (see Methemoglobinemia): one case report
  • Likely due to interaction between 4-thiofosfamide metabolite and glutathione -> resulting in oxidative stress

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References

• Pulmonary Complications of Novel Antineoplastic Agents for Solid Tumors. CHEST February 2008 vol. 133 no. 2 528-538