Indications
- Mantle Cell Lymphoma (see Lymphoma, [[Lymphoma]])
Adverse Effects
-
>10% (MCL)
Increased serum creatinine, 1.5 x ULN (67%)
Platelets decreased, all grades (57%)
Diarrhea (51%)
Hemorrhage (48%)
Neutrophils decreased, all grades (47%)
Hemoglobin decreased, all grades (41%)
Fatigue (41%)
Musculoskeletal pain (37%)
Peripheral edema (35%)
URI infection (34%)
Nausea (31%)
Bruising (30%)
Neutropenia, grades 3 or 4 (29%)
Dyspnea (27%)
Constipation (25%)
Rash (25%)
Abdominal pain (24%)
Vomiting (23%)
Decreased appetite (221%)
Cough (19%)
Pyrexia (18%)
Stomatitis (17%)
Thrombocytopenia, grades 3 or 4 (17%)
UTI infection (14%)
Pneumonia (14%)
Skin infections (14%)
Asthenia (14%)
Muscle spasms (14%)
Dizziness (14%)
Sinusitis (13%)
Headache (13%)
Dehydration (12%)
Dyspepsia (11%)
Petechiae (11%)
Arthralgia (11%)
Epistaxis (11%) -
>10% (CLL)
Platelets decreased, all grades (71%)
Diarrhea (63%)
Bruising (54%)
Neutrophils decreased, all grades (54%)
URT infection (48%)
Hemoglobin decreased, all grades (44%)
Fatigue (31%)
Rash (27%)
Musculoskeletal pain (27%)
Neutropenia, grades 3 or 4 (27%)
Pyrexia (25%)
Peripheral edema (23%)
Constipation (23%)
Arthralgia (23%)
Nausea (21%)
Stomatitis (21%)
Sinusitis (21%)
Dizziness (21%)
Vomiting (19%)
Cough (19%)
Muscle spasms (19%)
Headache (19%)
Skin infection (17%)
Petechiae (17%)
Decreased appetite (17%)
Hypertension (17%
Abdominal pain (15%)
Oropharyngeal pain (15%)
Dyspepsia (13%)
Asthenia (13%)
Chills (13%) -
1-10% (MCL)
Anemia, grades 3 or 4 (9%)
Increased serum creatinine, 1.5-3 x ULN (9%)
Hemorrhage, grades 3 or 4 (5%)
Secondary primary malignancies (5%) -
1-10% (CLL)
Pneumonia (10%)
UTI (10%)
Dyspnea (10%)
Peripheral neuropathy (10%)
Second malignancies (10%)
Anxiety (10%)
Insomnia (10%)
Thrombocytopenia, grades 3 or 4 (10%)
References
- xxx