Indications

• Chronic Myeloid Leukemia (CML) (see Chronic Myeloid Leukemia, [[Chronic Myeloid Leukemia]])
• Essential Thrombocytosis (see Essential Thrombocytosis, [Essential Thrombocytosis]])
• Human Immunodeficiency Virus (HIV) (see Human Immunodeficiency Virus, [[Human Immunodeficiency Virus]]): hydroxyura has anti-retroviral properties
• Polycythemia Vera (see Polycythemia Vera, [[Polycythemia Vera]])
• Psoriasis (see Psoriasis, [[Psoriasis]])
• Sickle Cell Disease (see Sickle Cell Disease, [[Sickle Cell Disease]])
• Systemic Mastocytosis (see Systemic Mastocytosis, [[Systemic Mastocytosis]])

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Pharmacology

• xxx

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Administration

• PO: xxx

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Adverse Effects

Hematologic Adverse Effects

• xxxx

Pulmonary Adverse Effects

• Acute/Subacute Pneumonitis (see Pneumonia, [[Pneumonia]])
  • Organizing Pneumonia (see Cryptogenic Organizing Pneumonia, [[Cryptogenic Organizing Pneumonia]])
• Interstitial Lung Disease (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])
  • Desquamative Interstitial Pneumonia (DIP) (see Desquamative Interstitial Pneumonia, [[Desquamative Interstitial Pneumonia]])
  • Non-Specific Interstitial Pneumonitis (NSIP) (see Non-Specific Interstitial Pneumonia, [[Non-Specific Interstitial Pneumonia]])
  • Pulmonary Fibrosis

Other Adverse Effects

• xxxx
• xxxx

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References

• Pulmonary fibrosis after prolonged therapy with 1,3-bis (2-chloroethyl)-1-nitrosourea. Chest 1977;72;372-3 1977
• Hydroxyurea-induced acute alveolitis in a patient with chronic myeloid leukaemia. Cancer chemotherapy and pharmacology 1990;27;168-9 1990
• Acute alveolitis induced by hydroxyurea in a patient with myeloproliferative syndrome. Annals of hematology 1993;67;133-4 1993
• Hydroxyurea-induced acute interstitial lung disease. Southern medical journal 1994;87;767-9 1994
• Recurrent pyrexia, cough and dyspnoea with hydroxyurea. Australian and New Zealand journal of medicine 1998;28;347 1998
• Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia. Annals of hematology 1999;78;187-8 1999
• Acute interstitial pneumopathy with fever caused by hydroxyurea. Presse médicale (Paris, France : 1983) 2000;29;242-5 2000
• Hydroxyurea-induced hypersensitivity pneumonitis: A case report and literature review. Canadian respiratory journal : journal of the Canadian Thoracic Society 2000 Nov-Dec;7;491-5 2000 Nov-Dec
• Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure. European journal of haematology 2003;71;388-90 2003
• Hydroxyurea-induced pneumonitis. Medizinische Klinik (Munich, Germany : 1983) 2003;98;394-7 2003
• Fulminant bronchiolitis obliterans organizing pneumonia following 2 d of treatment with hydroxyurea, interferon-alpha and oral cytarabine ocfosfate for chronic myelogenous leukemia. European journal of haematology 2004;73;67-70 2004
• Yet another cause for drug-induced pulmonary fibrosis. Journal of postgraduate medicine 2005 Jan-Mar;51;76-7 2005 Jan-Mar
• Hydroxycarbamide-induced pneumonitis. Histopathology 2009;55;234-6 2009
• Hydroxyurea-induced pneumonia. Revue des maladies respiratoires 2014;31;430-4 2014
• Hydrocycarbamide induced fever: Four cases and literature review. La Revue de medecine interne / fondee … par la Societe nationale francaise de medecine interne 2014;; 2014
• Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature. European review for medical and pharmacological sciences 2014;18;190-3 2014