Pharmacology

• Interference with NMJ transmission
• Hypoventilation leads to hypoxia/acidosis

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Side Effects

• Aminoglycoside-Related Neuromuscular Toxicity: resembles Botulism
  • Predisposing Factors
    • Myasthenia Gravis
    • ARF/CRF
  • Diagnosis
    • PFT’s: restriction
    • CXR: low lung volumes
  • Symptoms: diplopia, dysphagia, dyspnea, dysarthria
• Acute Kidney Injury with ATN (see Acute Kidney Injury):

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Treatment

• Discontinue drug: recovery within hours-days
• Anticholinesterase agents: useful for aminoglycoside neuromuscular toxicity

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References

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