Epidemiology

• Indications
  • Non-small cell lung cancer who do not respond to platinum-based chemo agents

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Pharmacology

• Tyrosine Kinase Inhibitor: epidermal growth factor receptor (EGFR) antagonist

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Adverse Effects

• Acute Interstitial Pneumonia/Acute Lung Injury-ARDS (see ILD-Etiology, [[ILD-Etiology]] and Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
  • Epidemiology: occurs in 1% of cases
    • Nested case control study in Asian population: incidence of 4.5 per 1000 persons over 12-week period
  • Diagnosis
    • Chest CT: ground-glass infiltrates
    • OLB: diffuse alveolar damage
  • Clinical
    • Acute Lung Injury-ARDS: may occur
  • Treatment: corticosteroids might be helpful
  • Prognosis: 30% mortality

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References

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