Indications
- Ascites (see Ascites, [[Ascites]])
- Congestive Heart Failure (CHF) (see Congestive Heart Failure, [[Congestive Heart Failure]])
- Edema
- Cirrhosis
- Congestive Heart Failure (CHF) (see Congestive Heart Failure, [[Congestive Heart Failure]])
- Renal Failure: nephrotic syndrome, etc
- Hypertension (see Hypertension, [[Hypertension]])
Pharmacology
- Npn-Sulfonamide Loop Diuretic: inhibition of sodium-potassium-chloride cotransport in the ascending loop of Henle
- Unlike the other loop diuretics, ethacrynic acid is not a sulfonamide (therefore, Its use is not contraindicated with sulfa allergy)
- Inhibition of Glutathione S-Transferases: due to ethacrynic acid itself and its glutathione adduct
- Glutathione S-transferases are involved in xenobiotic metabolism
Administration
- PO:
- IV:
Adverse Effects
Renal Adverse Effects
- Hypokalemia (see Hypokalemia, [[Hypokalemia]])
- Hypomagnesemia (see Hypomagnesemia, [[Hypomagnesemia]])
Other Adverse Effects
- Increased Risk of Gastric Hemorrhage Associated with Corticosteroid Treatment
- Ototoxicity with Reversible/Permanent Hearing Loss: more commonly occurs in patients with severe renal impairment
- May also increase the ototoxicity of other drugs, such as aminoglycosides and cephalosporins
References
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