Epithelial Sodium Channel Antagonists (ENaC Antagonists)
Agents
- Amiloride (Midamor) (see Amiloride, [[Amiloride]])
- Cimetidine (Tagamet) (see Cimetidine, [[Cimetidine]])
- Nafamostat: synthetic serine protease inhibitor, used as an anticoagulant
- Pentamidine (Nebupent) (see Pentamidine, [[Pentamidine]])
- Triamterene (Dyrenium, Dyazide, Maxzide) (see Triamterene, [[Triamterene]])
- Trimethoprim (see Sulfamethoxazole-Trimethoprim, [[Sulfamethoxazole-Trimethoprim]])
Pharmacology
- Inhibit Sodium Channels on the Luminal Membrane of Cells in the Renal Collecting Tubule: the collecting tubule is the site of action of aldosterone
References