Indications

• Atrial Fibrillation (see Atrial Fibrillation, [[Atrial Fibrillation]])

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Pharmacology

• xxx

Metabolism

• xxx

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Administration

• PO: xxx

Dose Adjustment

• Hepatic
• Renal

Drug Interactions

• Digoxin (see Digoxin, [[Digoxin]]): dronedarone increases digoxin levels (via P-glycoprotein interaction)
  • Permanent Atrial Fibrillation Outcome Study Using Dronedarone On Top Of Standard Therapy (PALLAS) Trial (2015) [MEDLINE]: dronedarone is associated with both increased cardiovascular death and heart failure in patients with permanent atrial fibrillation
    • There was a strong effect of concurrent digoxin use on the adverse effect of dronedarone on cardiovascular death (in patients on digoxin, there were 11 arrhythmic deaths on dronedarone and none on placebo; in patients not on digoxin, there were 2 arrhythmic deaths on dronedarone and 4 on placebo)
    • There was no interaction between baseline digoxin use and the adverse effect of dronedarone on heart failure events

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Adverse Effects

Pulmonary Adverse Effects

• Interstitial Lung Disease (ILD) (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])

Other Adverse Effects

• xxxxx
• xxxxx
• xxxxx

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References

• Interaction between digoxin and dronedarone in the PALLAS trial. Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1019-25. doi: 10.1161/CIRCEP.114.002046. Epub 2014 Nov 6 [MEDLINE]