Docetaxel (Taxotere)

Indications

Non-Small Cell Lung Cancer (see Lung Cancer, [[Lung Cancer]])
Breast Cancer (see Breast Cancer, [[Breast Cancer]])
Transitional Cell Cancer (see Urothelial Cell Cancer, [[Urothelial Cell Cancer]])
- Bladder Cancer (see Bladder Cancer, [[Bladder Cancer]])

Pharmacology

Taxane (see Taxanes, [[Taxanes]]): taxanes are diterpenes produced by the plants of the genus Taxus (yews)
- Docetaxel (Taxotere)
- Paclitaxel (Taxol) (see Paclitaxel, [[Paclitaxel]])

Administration

Adverse Effects

Acute or Subacute Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])

Epidemiology: increased risk of lung toxicity when used in combination with Gemcitabine (see Gemcitabine, [[Gemcitabine]])
Treatment: responsive to corticosteroids (see Corticosteroids, [[Corticosteroids]])

Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])

Clinical: xxx

Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]])

Clinical: xxx

Diffuse Alveolar Hemorrhage (see Diffuse Alveolar Hemorrhage, [[Diffuse Alveolar Hemorrhage]]): absence of pulmonary capillarities (bland alveolar hemorrhage)

Clinical: xxx

References

Docetaxel. J Clin Oncol 1995; 13: 2643-2655
Docetaxel and interstitial pulmonary injury. Ann Oncol 1997; 8: 191-194
Pneumopathie interstitielle diffuse aiguë sous docetaxel (Taxotere). Rev Mal Respir 1998; 15: 199-203
Severe pulmonary toxicity in patients treated with combination of docetaxel and gemcitabine for metastatic transitional cell carcinoma. Ann Oncol 1999; 18: 943-947
Severe pulmonary toxicity in patients treated with a combination of docetaxel and gemcitabine for metastatic transitional cell carcinoma. Annals of Oncology 1999; 10: 943-947
Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics 2000; 5: 1245-1259
Chemotherapy-induced noncardiogenic pulmonary edema related to gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor support. Respiration 2000; 67: 680-3
Severe interstitial pneumonitis following high-dose cyclophosphamide, thiotepa and docetaxel: two case reports and a review of the literature. Bone Marrow Transplantation 2001; 27: 559-563
Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere). British Journal of Cancer 2001; 85: 1247-1250
Severe interstitial pneumonitis associated with docetaxel administration. Cancer 2002; 94: 847-853
High incidence of pulmonary toxicity of weekly docetaxel and gemcitabine in patients with non-small cell lung cancer: results of a dose-finding study. Lung Cancer; Volume 44, Issue 3, June 2004, Pages 363-368
Docetaxel-induced acute pulmonary capillary-leak syndrome mimicking cardiogenic oedema. Ann Fr Anesth Reanim 2007; 26: 180-1