Disulfiram (Antabuse)



Disulfiram is a thiuram derivative which interferes with aldehyde dehydrogenase.

When taken concomitantly with alcohol, there is an increase in serum acetaldehyde levels. High acetaldehyde causes uncomfortable symptoms including flushing, nausea, thirst, palpitations, chest pain, vertigo, and hypotension.

This reaction is the basis for disulfiram use in postwithdrawal long-term care of alcoholism.



Dose Adjustment

Adverse Effects

Dermatologic Adverse Effects

Neurologic Adverse Effects

Gastrointestinal Adverse Effects

Genitourinary Adverse Effects

Ophthalmologic Adverse Effects

Adverse Effects (Disulfiram Intoxication)

Neurologic Adverse Effects

Otolaryngologic Adverse Effects

Adverse Effects (Disulfiram-Ethanol Reaction)

General Comments

Allergic Manifestations

Cardiovascular Manifestations

Dermatologic Manifestations

Gastrointestinal Manifestations

Treatment of Disulfiram-Ethanol Reaction